Thermal-mechanical fatigue crack growth in Inconel X-750

Thermal-mechanical fatigue crack growth (TMFCG) was studied in a gamma-gamma' nickel base superalloy Inconel X-750 under controlled load amplitude in the temperature range from 300 to 650 C. In-phase (T sub max at sigma sub max), out-of-phase (T sub min at sigma sub max), and isothermal tests at 650 C were performed on single-edge notch bars under fully reversed cyclic conditions. A dc electrical potential method was used to measure crack length. The electrical potential response obtained for each cycle of a given wave form and R value yields information on crack closure and crack extension per cycle. The macroscopic crack growth rates are reported as a function of delta k and the relative magnitude of the TMFCG are discussed in the light of the potential drop information and of the fractographic observations

Equalization and the Decentralization of Revenue-Raising in a Federation

We study federal economies in which regional governments have responsibility for delivering public services and redistributive objectives apply. The implications of these for the assignment of revenue-raising instruments and fiscal transfers, both vertical and horizontal, are considered. Models of heterogenous regions of varying degrees of complexity and generality are constructed. For each case, we determine what fiscal instruments must be given to the regions and what inter-governmental transfers must be made in order that the social optimum is achieved. With heterogenous households and regions, the social optimum can be decentralized by making regions responsible for redistribution and implementing equalization transfers that depend on the number of households of each type.

Self-Referential Thinking, Suicide, and Function of the Cortical Midline Structures and Striatum in Mood Disorders: Possible Implications for Treatment Studies of Mindfulness-Based Interventions for Bipolar Depression

Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS) appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking with functional imaging of CMS and striatal function may help delineate the neurobiological mechanisms of action of these treatments

The Use of Argumentation in Socio-Scientific Issues: Enhancing Evolutionary Biology Instruction

With the adoption of the Next Generation Science Standards (NGSS), further emphasis in science education is being placed on preparing students to become more informed voters regarding social, ethical, economic and political topics that affect contemporary society. Parallel to this shift is a stronger emphasis on integrating evolutionary theory as a unifying concept in the biological sciences. Given that evolution is one of the aforementioned topics commonly discussed and debated about in social and political arenas, ensuring that instruction provides students from all backgrounds a comprehensive understanding of its principals is becoming increasingly important in contemporary science education. Chapter II of this project functions as a review of contemporary literature that will be utilized to help determine the best methodology for enhancing instruction and comprehension of prominent Socio-Scientific Issues (SSI) like evolution. Literature suggests that using argumentation to engage students in socially controversial scientific content may enhance comprehension and retention of material. More specifically, since evolution is a SSI that is often perceived by some to challenge individuals’ religious and ethical beliefs, engaging students in the content is often difficult using traditional methods that do not allow alternative, non-scientific ideologies to be incorporated. Therefore, it is suggested that the incorporation of a data driven, formal argumentation that allows students the option to argue either for or against evolution may serve to increase the level of engagement of the student body as a whole in evolutionary content. Chapter III of this project is a unit planned designed to incorporate data driven SSI argumentation into an evolutionary context. Through the use of five case studies, students will be introduced to the raw data that is used by evolutionary biologists to support evolutionary theory. Using these activities, students will collaboratively analyze the data, and be asked to decide individually whether to use it to support evolutionary theory or creationism. Subsequently, the formal argumentation piece is designed to engage all students in active argumentation using debate questions related to each case study

Simple model for post seismic ionospheric disturbances above an earthquake epicentre and along connecting magnetic field lines

The detection of ionospheric disturbances associated with seismic activity is one of the main objectives of the DEMETER micro-satellite. Its scientific payload provides a comprehensive set of electron and ion measurements. The present work describes a simple model of post-seismic disturbances in the ionosphere above the epicentre. Following a major seism, the neutral atmosphere is assumed to be subject to an acoustic pulse propagating upward, to high altitudes. By coupling this perturbation to the two-dimensional ionospheric model SAMI2 it is then possible to calculate the variations in a number of plasma parameters in the plume region and along connecting magnetic field lines, for an event of representative magnitude. The feasibility of identifying the signature of seismic events from satellite observations is then assessed in view of representative DEMETER measurements and of their natural variability

Multiangle observations of Arctic clouds from FIRE ACE: June 3, 1998, case study

In May and June 1998 the Airborne Multiangle Imaging Spectroradiometer (AirMISR) participated in the FIRE Arctic Cloud Experiment (ACE). AirMISR is an airborne instrument for obtaining multiangle imagery similar to that of the satellite-borne MISR instrument. This paper presents a detailed analysis of the data collected on June 3, 1998. In particular, AirMISR radiance measurements are compared with measurements made by two other instruments, the Cloud Absorption Radiometer (CAR) and the MODIS airborne simulator (MAS), as well as to plane-parallel radiative transfer simulations. It is found that the AirMISR radiance measurements and albedo estimates compare favorably both with the other instruments and with the radiative transfer simulations. In addition to radiance and albedo, the multiangle AirMISR data can be used to obtain estimates of cloud top height using stereoimaging techniques. Comparison of AirMISR retrieved cloud top height (using the complete MISR-based stereoimaging approach) shows excellent agreement with the measurements from the airborne Cloud Lidar System (CLS) and ground-based millimeterwave cloud radar

Aberrant functional connectivity of cortico-basal ganglia circuits in major depression

ManuscriptThere is considerable evidence of functional abnormalities of the cortico-basal ganglia circuitry in affective disorders. However, it has been unknown whether this represented primary pathology within these circuits or altered activation as a result of aberrant input from other brain regions. The aim of this study was to test the hypothesis that cortico-basal ganglia circuit dysfunction represents primary pathology in unipolar depression. Eighteen male subjects with recurrent unipolar depression and eighteen controls without psychiatric illness were studied using functional MRI and functional connectivity analyses. All unipolar subjects were unmedicated and without current psychiatric comorbidity. Compared to controls, unipolar subjects exhibited altered connectivity between bilateral subcortical components of the circuitry (putamen-thalamus) and left hemisphere input and output components. Results provided evidence that functional abnormalities of these circuits represent primary pathology. Further, we found that age of onset but not duration of illness impacts circuit function. These findings suggest that the cortico-basal ganglia circuitry is likely one of several loci of primary pathology in major depression. Additionally, early age of onset is associated with greater circuit abnormality and as such may impact clinical characteristics and/or treatment response through a mechanism of decreasing functional connectivity of some circuit segments. Finally, altered cortico-basal ganglia circuit connectivity with cortical regions (anterior cingulate, inferior frontal gyrus and sensorimotor) may contribute to the emotional dysregulation, impaired emotional recognition and psychomotor symptoms associated with unipolar illness